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Ro 20-1724

CAS No. 29925-17-5

Ro 20-1724 ( Ro20-1724; Ro 20-1724; Ro-20-1724; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone )

Catalog No. M27133 CAS No. 29925-17-5

Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 20-1724
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
  • Description
    Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.(In Vivo):RO-20-1724 was found to not only improve learning and memory in MWM and PA paradigms but also restore STZ induced elevation in cholinesterase activity. Further, RO-20-1724 significantly reduced malondialdehyde and nitrite levels, and restored the glutathione levels indicating attenuation of oxidative stress.
  • Synonyms
    Ro20-1724; Ro 20-1724; Ro-20-1724; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    IL-8; NOD2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    29925-17-5
  • Formula Weight
    278.4
  • Molecular Formula
    C15H22N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1.
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